How might the future of science advice look at the global level? Will the establishment of a UN Group of Friends on Science for Action be the catalyst that elevates science advice to the highest levels of multilateral decision-making, and how will this complement the Secretary-General's renewed scientific advisory board? And what should the role of the international science community be? In this episode, Dr Salvatore Aricò, chief executive of the International Science Council, shares his experience and his vision with Toby Wardman, drawing on practical examples to illustrate how such science advice mechanisms work in practice. We also discuss the challenges and opportunities for scientists and the ISC that can help translate science into action, policy-relevant advice.